ALBENDAZOLE

COMPOSITION:

Each 100 ml contain:

• Albendazole 5 Gm.

• Excipient up to 100 Ml

MODE OF ACTION:

Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

ANTHHELMINTIC SPECTRUM:

nematodes, lung worms, cestodes and trematodes.

PROPERTIES:

• Albendazole, is a broad spectrum anthelmintic related to benzimidazoles.

• Albendazole, is slowly absorbed and slowly excreted from the GIT thus it gives long lasting effect.

• Albendazole is rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is further metabolized to albendazole sulfone and other primary oxidative metabolites that excreted in urine.

• highly effective against, nematodes, lung worms, cestodes and trematodes .

• Albendazole, has a good ovicidal effect and can be used safely in cattle, sheep, goats, poultry, dogs and cats.

• Albendazole, is effective against mature and immature stages of many worms like bunostomum, chabertia, haemonchus, nematodirus, ostertagia, trichostrongylus & trichurius spp., Dictyocaulus viviparous, D. filaria, ascaridia galli, capillaria, moniezia spp., syngamus trachease, raliatina and devania in poultry.

INDICATIONS:

Cattle Sheep and Goats:

Albendazole is a broad spectrum anthelmintic, used for treatment of mature & immature stages worm infestation, it is highly effective against the following:

• Gastrointestinal round nematodes (Bunostomum, Chabertia, Haemonchus, Ostertagia, Trichostrongylus and Trichurisspp.).

• Lungworms (Dictyocaulus viviparous & D.filaria).

• Tapeworm (Monieziaspp).

• Liver flukes (adult stages of Fasciola hepatica & F.gigantica).

Dogs and cats:

Filariasis.

Poultry:

devania

TARGET SPECIES:

Cattle, Sheep, Goats, Dogs, cats and poultry.

DOSAGE AND ADMINISTRATION:

Shake well before use and given orally as one dose.

Cattle, Horses:

• For different worms 3 ml / 20 kg b.wt. (7.5 mg / kg B.wt.)

• For liver fluke 4 ml / 20 kg B.wt. (10 mg / kg b.wt.)

Sheep & Goats:

• For different worms 2 ml / 20 kg B.wt. (5 mg / kg B.wt.)

• For liver fluke 3 ml / 20 kg b.wt. (7.5 mg / kg b.wt. )

Dogs & Cats:

• For different worms 2 ml / 20 kg b.wt. (5 mg / kg b.wt.)

Poultry :

• 400 ml / ton B.Wt. (20 mg / Kg B.Wt.)

WARNING& PRECAUTIONS:

• Keep out of reach of children.

• For Veterinary use only .

• To be used by Veterinary Prescription Order.

• Restricted dose must be followed .

• During treatment use the medicated water as only source for drinking.

• Milk produced during treatment should not be used for human consumption.

• Safe even double dose is given to the animal.

• Shake well before use.

PACKAGE DESCRIPTION:

1 liter plastic bottle.

STORAGE CONDITIONS:

• Store in dark place, away from direct sunlight under dry conditions at or below 25°C.

• Store in closed packing.
  

WITHDRAWAL TIME:

According national regulations.