GRELEC PLUS
IVERMECTIN & CLORSULON Injection
ANTHELMINTICRUMINANTS
COMPOSITION:
Each 100 ml contains:
Ivermectin 1 Gm .
Clorsulon 10 Gm.
Excipient up to 100 Ml
MODE OF ACTION:
Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action.
Ivermectin paralyses and ultimately kills parasitic nematodes, arachnids and insects by a unique act on the nervous system of these parasites. It activates glutamate sensitive chloride ion channels in invertebrate muscle and nerve cells. It also acts the release and binding of gamma-aminobutyric acid (GABA) which opens chloride channels in nerves. The chloride channels are open when they should be closed, and signals are not received by the end-cell. The process is irreversible and leads to paralysis and death.
Mammals do not have glutamate mediated chloride channels and GABA mediated nerves occur only in the central nervous system, whereas in the invertebrate such nerves regulate the peripheral muscles. Ivermectin does not readily cross the blood brain barrier with no notable
act on mammalian GABA binding. Therefore ivermectin has a wide margin of safety in mammals.
Clorsulon is rapidly absorbed into the circulating blood. Erythrocytes with bound drug, as well as plasma, are ingested by Fasciola hepatica (liver flukes). Adult flukes are killed by clorsulon because of inhibition of enzymes in the glycolytic pathway, which is their primary source of energy.
ANTHHELMINTIC SPECTRUM:
nematodes, lung worms, cestodes, trematodes, external parasite and Adult liver fluke .
PROPERTIES:
Ivermectin is a member of the macrocyclic lactone class of endectocides, clorsulon Is active against adult and immature (6-8) weeks liver flukes.
Ivermectin is an avermectin which a group of pentacyclic sixteen-membered lactone (i.e. a macrocyclic lactone disaccharide), clorsulon Is one of Sulphonamide fasciolicidal agent.
Ivermectin half-life period is 16 hours also reported at 22:28 hours, clorsulon Excretion half-life after oral administration is about 26 hours .
Ivermectin and clorsulon are very fast distributed from the site of injection and high concentrations of the drug are sustained in the tissues for long periods.
Ivermectin and /or its metabolites are mostly excreted through the liver in the feces (98%:99%) over an estimated 12 days and (1:2 %) of the administered dose excreted in the urine , clorsulon excreted unchanged through urine.
Ivermectin, clorsulon is used for elimination of internal and external parasites.
Ivermectin, clorsulon has an acceptable safety margin, the administration of 25 ml per 50 kg bodyweight (25 x the use level) resulted in injection site lesion (including tissue necrosis, oedema, fibrosis and inflammation)..
Ivermectin, clorsulon has on teratogenic or embryotoxic effects in any of the species tested.
Ivermectin, clorsulon acts with an unique mode of action and is structurally different from the presently available parasiticdes.
No other drug-related adverse reactions could be determined .
Ivermectin, clorsulon act on :
Gastrointestinal roundworms (adult and fourth-stage larvae):
Ostertagia spp. (including inhibited O. ostertagi), Haemonchus placei, Trichostrongylus axei, T. colubriformis,Cooperia spp., Bunostomum phlebotomum, Oesophagostomum radiatum, Strongyloides papillosus (adult only), Nematodirus helvetianus (adult only), N. spathiger (adult only), Toxocara vitulorum,Trichuris spp. (adult only)
Lungworms (adult and fourth-stage larvae): Dictyocaulus viviparus
Liver fluke (adult): Fasciola hepatica
Eye worms (adult): Thelazia spp.
Warbles (parasitic stages): Hypoderma bovis, H. lineatum
Mange mites: Psoroptes bovis, Sarcoptes scabiei var. bovis
Sucking lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus.
Ivermectin, clorsulon in Cattle may also be used as an aid in the control of biting lice (Damalinia bovis) and the mange mite Chorioptes bovis, but complete elimination may not occur.
Indications:
Gastrointestinal roundworms (adult and fourth-stage larvae): Ostertagia spp. (including inhibited O. ostertagi), Haemonchus placei, Trichostrongylus axei, T. colubriformis,Cooperia spp., Bunostomum phlebotomum, Oesophagostomum radiatum, Strongyloides papillosus (adult only), Nematodirus helvetianus (adult only), N. spathiger (adult only), Toxocara vitulorum,Trichuris spp. (adult only)
Lungworms (adult and fourth-stage larvae): Dictyocaulus viviparus
Liver fluke (adult): Fasciola hepatica
Eye worms (adult): Thelazia spp.
Warbles (parasitic stages): Hypoderma bovis, H. lineatum
Mange mites: Psoroptes bovis, Sarcoptes scabiei var. bovis
Sucking lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus.
TARGET SPECIES:
Cattle, Sheep, Goats, and Camel .
DOSAGE AND DIRECTIONS FOR ADMINISTRATION:
One ml /50 Kg. B. Wt. By subcutaneous injection.
WARNING& PRECAUTIONS:
Keep out of reach of children.
For Veterinary use only .
To be used by Veterinary Prescription Order.
This product should be given by subcutaneous injection only.
This product is not to be used intravenously or intramuscularly.
Restricted dose must be followed.
Under dosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device .
Using a sterile needle with a gauge of (15-20) mm..
Inject the dose under the loose skin behind or in front the shoulder.
In wooly sheep, be sure that the needle has aseptically penetrated the wool and skin before delivering the dose.
If the dose exceed 10 ml Divide it between different injection sites and use different sites to those used for other parenteral medications.
Swab septum before removing each dose.
Milk produced during treatment should not be used for human consumption.
The person administering the product must not smoke or eat while handling the product.
This product is safe even tenfold dose is given to the animal.
This product should not be used intravenously or intramuscularly.
A low incidence of soft tissue swelling at the site of injection and transitory discomfort has been observed is some livestock.
Take care to avoid self-administration.
Wash hands after use.
This product is safe for use at any stage of pregnancy or lactation.
This product will not affect the fertility of cows and bulls and can be given to all ages of animals including young calves.
PACKAGE DESCRIPTION:
50 ml amber glass vials .
STORAGE CONDITIONS:
Store in dark place, away from direct sunlight under dry conditions at or below 25°C.
Store in closed packing.
WITHDRAWAL TIME:
According national regulations.
