VALCEAR

Composition:

Each 1 gm contain:

Valnemulin hydrochloride 532.5 mg

(eq. to valnemulin base 500 mg).

Properties:

• Valnemulin is an antibiotic belonging to the pleuromutilin group, which acts by the inhibition of the initiation of protein synthesis at the level of the bacterial ribosome.

• Valnemulin has activity against a range of bacteria including those responsible for enteric and respiratory disease in pigs.

• Valnemulin shows high activity against Mycoplasma spp. and spirochaetes such as Brachyspira hyodysenteriae and Brachyspira pilosicoli in swine.

• Clostridium perfringens, a bacterium which may be involved in the development of ERE.

• Valnemulin has little activity against Enterobacteriaceae, such as Salmonella spp. and Escherichia coli.

Target Species :

Pigs

Indications :

• Treatment of swine dysentery which caused by Brachspira hyodysenteriae.

• Treatment of clinical signs of porcine proliferative enteropathy (ileitis) which caused by Lawsonia intracellularis .

• Treatment of swine enzootic pneumonia which caused by Mycoplasma hyopneumoniae

Dosage and administration:

Route of administration:

Orally with feed.

For whole product :

• Treatment of swine dysentery: 150 mg of the product/kg feed for a minimum of 7 days and up to 4 weeks or until signs disappear .

• Treatment of clinical signs of porcine proliferative enteropathy (ileitis) : 150 mg of the product /kg feed for 2 weeks or until signs of disease disappear .

• Treatment of swine enzootic pueumonia : 400 mg of the product /kg feed for up to 3 weeks.

Warning and percuation:

• When treating infections caused by Brachyspira spp., therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria

• Valnemulin has been shown to interact with ionophores such as monensin, salinomycin and narasin and may result in signs indistinguishable from an ionophore toxicosis.

• Animals should not receive veterinary medicinal products containing monensin, salinomycin or narasin, during or at least 5 days before or after treatment with valnemulin. Severe growth depression, ataxia, paralysis or death may result.

Contra-indications:

Do not administer the veterinary medicinal product to pigs receiving the ionophores monensin, salinomycin or narasin.

Side effects:

• Most common adverse reactions observed in these pigs are pyrexia, anorexia and in severe cases ataxia and recumbency.

• A percentage of such pigs may also suffer oedema or erythema (posterior in distribution), and palpebral oedema.

Withdrwal time:

Meat and offal

Pigs: 1 day.

Storage condations:

• Store at temperature not more than 30°C in dry place .

• use immediately after opend

Packaging:

Transparent LDPE plastic bag contains 100 Gm Powder to be mixed with feed in easy opened tin container with outer label.