ZOLEX

COMPOSITION:

Each 500 Gm contains:

• Diclazuril 1 Gm

• Excipient up to 500 Gm

MODE OF ACTION:

Although the mode of action of diclazuril is not precisely known, its effect on the asexual or sexual stages of coccidies blocks the excretion of oocysts inducing an interruption of the life cycle of the parsites.

ANTICOCCIDIAL SPECTRUM:

In chickens affect on:

Eimeria acervulina, E. brunetti, E. maxima, E. mitis, E. praecox, E. necatrix and E. tenella.

In turkeys affect on:

Eimeria adenoeides, E. meleagrimitis and E. gallopavonis.

In rabbits affect on:

Eimeria irresidua, E.media, E. flavescens, E. intestinalis, E. perforans, E. piriformis, E. stiedai, E. magna, E.exigua and E.coecicola.

in guinea fowls affect on:

Eimeria numidae and E. grenieri.

PROPERTIES:

• Diclazuril is a chemical anticoccidial, a benzeneacetonitrile derivative – synthetic compound of the triazinone family.

• Zolex is very stable under the influence of heat (kept stable in H2O at 100˚C) ,moisture (un changed at steam,135˚C) and not oxidized in an environment of 60˚C.

• Diclazuril is active against intracellular development stages of coccidia, namely during schizogony and gametogony.

• Ultrastructural findings indicate that diclazuril treatment primarily affects the normal differentiation of the respective endogenous stages during parasite development, This leads to complete degeneration of schizonts and gamonts.

• Diclazuril reach the maximum plasma level after 8 hours post oral administration.

• Diclazuril excreted unchanged in urine and nearly 90% in the faeces.

• After diclurazil treatment, the first- and second-generation schizonts show extensive degenerative changes which are characterised by the loss of internal structure, the appearance of many intracytoplasmic vacuoles and incomplete merogony.

• Diclazuril affect on: Eimeria acervulina, E. brunetti, E. maxima, E. mitis, E. praecox, E. necatrix , E. tenella, Eimeria adenoeides, E. meleagrimitis, E. gallopavonis, Eimeria irresidua, E.media, E. flavescens, E. intestinalis, E. perforans, E. piriformis, E. stiedai, E. magna, E.exigua and E.coecicola, Eimeria numidae and E. grenieri.

TARGET SPECIES:

Chickens, turkeys, rabbits and guinea fowls.

DOSAGE AND DIRECTIONS FOR ADMINISTRATION:

Use Zolex 0.5 Kg / metric ton feed (diclazuril 1 PPM)

medicated feed as the sole ration, from one day of age up until slaughter.

MIXING DIRECTIONS:

It is recommended that a premix be made from ZOLEX before final mixing. It is suggested to premix 500 grams of ZOLEX with 20-50 kg of a feed ingredient (or vitamin-mineral mixture) before incorporating in the feed.

WARNING& PRECAUTIONS:

• Keep this and all medication out of reach of children.

• For Veterinary use only .

• To be used by Veterinary Prescription Order.

• Restricted dose must be followed .

• For Feed Manufacturing Use Only.

• Not for use in hens producing eggs for human food.

• Use the medicated feed as only source of feed.

PACKAGE DESCRIPTION:

500 gm plastic bag inside carton pox, 15 Kg in 4 layers bag .

STORAGE CONDITIONS:

• Store in dark place, away from direct sunlight under dry conditions at or below 25°C.

• Store in closed packing.
  

WITHDRAWAL TIME:

According national regulations.