GRELEC
IVERMECTIN INJ.
ANTHELMINTICRUMINANTS
COMPOSITION:
Each 100 ml contains:
Ivermectin 1 Gm .
Excipient up to 100 Ml
MODE OF ACTION:
Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Ivermectin may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms.
ANTHHELMINTIC SPECTRUM:
nematodes, lung worms, cestodes, trematodes, external parasite .
PROPERTIES:
Ivermectin is a semisynthetic anthelminitic.
Ivermectin is an avermectin which a group of pentacyclic sixteen-membered lactone (i.e. a macrocyclic lactone disaccharide)
Ivermectin half-life period is 16 hours also reported at 22:28 hours .
Ivermectin very fast distributed from the site of injection and high concentrations of the drug are sustained in the tissues for long periods.
Ivermectin and /or its metabolites are mostly excreted through the liver in the feces (98%:99%) over an estimated 12 days and (1:2 %) of the administered dose excreted in the urine.
GREELEC is used for elimination of internal and external parasites.
GREELEC has an acceptable safety margin of greater than 30 times the recommended dose in cattle.
GREELEC has on teratogenic or embryotoxic effects in any of the species tested.
GREELEC acts with an unique mode of action and is structurally different from the presently available parasiticdes, so cross-resistance with any other antiparasitic agents is unlikely.
GREELEC when comes in contact with the soil, it has no polluting effect on the environment.
INDICATIONS:
GREELEC is indicated for the treatment and control of internal and external parasites as follow:
Cattle & Pigs:
Gastrointestinal roundworms: Mature and immature stages of Ostertagia spp., Haemonchus spp.,Trichostrongylus spp., Cooperia spp., Bunostomum spp., Obsophagostomum spp., Strongyloides papiliosus, Thelazia and Toxocara vitulorum.
Lung worms : mature & immature stages of Dictyocaulus viviparus.
Tropical cattle grub: Hypoderma spp. Dermatobia, Screw-worm fly.
External parasite as: Lice, Ticks, Nasal bot and mange .
In Sheep & Goats:
Gastrointestinal roundworms: mature & immature stages of Ostertagia spp, Haemonchus contortus , Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Chabertia ovina, Nematodirus and Trichurisovis.
Lung worms: mature & immature stages of Dictyocaulus filaria.
Nasal bot: All larval stages of Oestrus ovis.
External parasite as: Lice, Ticks, Nasal bot and mange .
In Camels:
Gastrointestinal round worms: mature and immature stages of Camel-strongylus, Haemonchus Ostertagia, Trichostrongylus spp., Oesophagostomum and chabertia.
External parasite as: Lice, Ticks, Nasal bot and mange .
TARGET SPECIES:
Cattle, Sheep, Goats, and Camel .
DOSAGE AND DIRECTIONS FOR ADMINISTRATION:
For all species :
1 ml/ 50 kg B. Wt. by subcutaneous inj. (200 mcg / Kg B. Wt.).
Proper timing for treatment cattle with grubs is important as soon as possible after the end of waeble fly season.
Cattle treated with GREELEC after the end of the fly season may be treated with GREELEC during the winter for internal parasites, mange mites or lice.
two injections at a 7 day interval are required to eliminate living mites in sheep, and 15 days interval for camels.
GREELEC injection at the recommended dosage, effectively controls infections with Ostertagia spp. And cooperia spp. Acquired up to at least 7 days after treatment, 14 days after treatment for Dictyocaulus viviparus and 14 days after treatment for the screw worm fly (Chrysoma bezziana) in cattle.
WARNING& PRECAUTIONS:
Keep out of reach of children.
For Veterinary use only .
To be used by Veterinary Prescription Order.
Restricted dose must be followed .
Using a sterile needle with a gauge of 16,15 or 10 mm..
Inject the dose under the loose skin behind or in front the shoulder.
In wooly sheep, be sure that the needle has aseptically penetrated the wool and skin before delivering the dose.
Milk produced during treatment should not be used for human consumption.
GREELEC is safe even tenfold dose is given to the animal.
GREELEC should not be used intravenously or intramuscularly.
A low incidence of soft tissue swelling at the site of injection and transitory discomfort has been observed is some livestock.
PACKAGE DESCRIPTION:
50 ml amber glass vials .
STORAGE CONDITIONS:
Store in dark place, away from direct sunlight under dry conditions at or below 25°C.
Store in closed packing.
WITHDRAWAL TIME:
According national regulations.
